Revatio And Pulmonary Arterial Hypertension (PAH)


Revatio And PAH

Revatio, much like Viagra, consists of the same active ingredient, Sildenafil Citrate. It is the dosage amount that decides what part of the body is going to be impacted. Lower doses of Sildenafil Citrate are responsible for treating PAH. Whereas higher and stronger doses are used to treat Erectile Dysfunction (ED). We shall be discussing how Revatio can help cure or at least ease the symptoms of Pulmonary Arterial Hypertension (PAH). 

Some people can become victims of high blood pressure due to clogged arteries. This occurs due to unhealthy dietary habits and excessive consumption of alcohol or even worse, nicotine. Fatty foods are another reason for clogged arteries. They get stocked in the bloodstream and lead to the formation of excess plaque.

This plaque blocks the smooth flow of blood, due to which high pressure builds up. This makes blood flow to the lungs non-uniform and makes it hard for the proper functioning of the organs. Fatigue, hypertension, excessive tiredness, and uneasiness begin to kick in. The solution to this is consuming Revatio.

Revatio contributes to the problem by broadening the blood vessels. This change in size stabilizes the blood flow to the lungs and eventually leads to normalization of blood flow to the heart. The main properties of the drug Revatio lead to PDE-5 (phosphodiesterase type 5) inhibiting effects within the body. PDE-5 is an enzyme that regulates the cGMP levels.

These cGMP levels are altered to transmit signals for basic muscle movements such as relaxation and contraction. Thus, when the activity of the PDE-5 enzyme is inhibited. The cGMP levels are increased and it becomes easier for the deep muscle movement to coordinate with blood circulation.

1. Dosage

Revatio comes under the category of vasodilatory medication due to its relaxing effects on the blood vessels.

If you are consuming Revatio for PAH then the following three dosage concentrations are available:

  • Injection – This is a one-time glass vial that consists of 10-mg / 12.5 ml of sildenafil. It must be done under medical supervision as the medicine needs to be injected into the veins, that too through an IV.
  • Tablets – There are 5 mg and 20 mg doses of Revatio. Depending on the severity of the condition, it must be consumed up to 3 times a day. Ensure that each of these doses is spaced out at an interval of 4 to 6 hours. If you are consuming the pills without medical supervision, then consider starting with small doses and gradually increasing your dosage amount as you begin to understand how much it is relieving your PAH issue. 
  • Oral Suspension – Revatio can also be purchased in powder forms consisting of up to 1.57 grams of Sildenafil Citrate. You will receive it in a plastic bottle that consists of approximately 1.12 grams of Sildenafil. You need to mix it with 90 ml of water and will get a mixture of 112 ml out of which there would be 10mg/ml Sildenafil.

2. Side Effects 

Compared to Viagra, the side effects of Revatio are much lesser. Expect flushing of the skin to occur due to more relaxed blood flow in parts that otherwise craved normal blood flow. Another issue is that due to the long period of unstable blood flow to the heart and lungs, sudden stability can take a while to adapt to.

Instances of insomnia and shortness of breath during the night can occur as your body is relaxed and the effects of Revatio are in full flow. Also, due to the change in blood pressure within the body. There can be some transfer of blood away from the optic nerve. This leads to visual disturbances in the form of blurriness.

Although there is nothing to worry about because as time passes the body gets used to Revatio and these side effects will cease to exist.

You may experience some of the uncommon side effects that do not occur in the majority of PAH victims. Side effects under this category can include back pain, muscle pain, urinary tract disturbances, mild fever, dizziness, and gastrointestinal issues.

This would usually occur due to some food that you must have consumed that does not interact well with Revatio. Although, the body is known to heal such issues and there is hardly any reason to worry.

You only have a reason to worry if you face any kind of itching sensation, tightness in the chest, difficulty in focusing (as the drug may have affected blood flow to the brain), or major unsteadiness while trying to walk or even stand.

3. Drug Interactions

  • The most important thing to remember if you consume Revatio is that under no circumstances can you consume other nitrate medications at the same time. Revatio functions by widening your blood vessels to solve the problem of high-pressure build-up. Nitrate medicines function in the same way and are usually alternate options to reduce high blood pressure problems. Riociguat is one such medicine that contains nitrates and mixing it with Revatio can lead to a life-threatening drop in blood pressure.
  • ED pills such as Viagra, Cialis, etc. are other pills that you cannot consume at the same time as Revatio. ED pills divert blood from other parts of the body to the pelvic region and they also lead to the relaxation of blood vessels. Revatio does the exact thing, except that it relaxes blood vessels leading to the lungs. If the blood vessels get too relaxed then the blood flow can damage the organs and lead to permanent organ damage.
  • Never mix Revatio with alpha-blockers or nitric oxide as the patient can fall into a state of partial or complete coma. This severe problem arises when there is an extremely low blood supply to the brain.

Revatio And PAH: Wrapping Up

The active ingredient Sildenafil inhibits cyclic guanosine monophosphate (cGMP) – specific PDE-5 enzymes. PDE-5 is the enzyme that leads to the degradation of cGMP in the pulmonary muscle cells. Due to restricting the release of PDE-5. There is an increase in cGMP and thus the arteries are rewarded with dilated blood vessels to the lungs and heart for a greater and more effective flow of blood.