Modafinil Alternatives: 7 Options That Actually Work

modafinil alternatives

In this article, we’ll share some effective alternatives to Modafinil that actually work just as good.

What Is Modafinil?

Modafinil is commonly sold under the name Provigil, its brand name. Its usage is very similar to that of Armodafinil, that is it helps overcome sleep daytime drowsiness and fatigue caused due to narcolepsy and obstructive sleep apnea (OSA). The consumption of this form of medication promotes wakefulness by changing the behavior or certain neurotransmitters in the brain.

Histamine, Norepinephrine, Glutamate, and Orexin levels are also adjusted to resolve whatever reason you are using Modafinil for. It has been dubbed as the “world’s safest smart drug” by esteemed researchers at Oxford and Harvard university due to its effect on increasing the amount of dopamine present in the synapses between brain cells.

Modafinil Alternatives

Modafinil is labeled as a schedule IV drug, thus there is a risk of addiction due to the euphoric effects induced after consumption. Also, due to the longer half-life of Armodafinil, it is a preferred drug to Modafinil. The fact that Modafinil takes about 3 to 4 hours to reach peak effects and another couple of hours before diminishing makes it less preferable to Armodafinil, which kicks in less than two hours.

Also, Modafinil is known to cause nausea and severe headaches more often than its usual alternative, Armodafinil. As the original manufacturer, Laboratorie Lafon, and the parent company Cephalon Inc. have ceased the production of this drug, many people are looking for a trustworthy and equally effective alternative of Modafinil.

1. Adrafinil

Adrafinil, this was the first generation of Modafinil tablets and is a fantastic legal alternative that offers identical health benefits. It is a mild nootropic supplement with a half-life of about 2 hours, and it stimulates the central nervous system to relieve users of immoderate sleepiness.

It has been chemically designed for patients suffering from shift work sleep disorders and is a synthetic drug, thus it obviously cannot be derived from natural food sources. Though its lasting effect is 6 hours, it is not even close to that of Modafinil, whose effects last for up to 12 hours. Another benefit is that it is significantly cheaper than Modafinil.

2. Noopept

N-phenylacteyl-L-polylglycine ethyl ester known by its brand name, Noopept, is a synthetic drug that can be promoted as a nootropic. It takes about 15 minutes to kick in and lasts for not more than an hour. Thus, its effects come into motion swiftly but last only for a short time.

It is the influence of serotonin and dopamine that helps combat stress, sleep, mood swings, and natural emotions. This neuroprotective effect is activated during diverse states of cognitive trauma, also including physical trauma and oxidative stress.  Consuming 10-30 mg per day for 8 weeks shall show significant improvement in sleep disorders.

3. Flurenol

Fluorenol is a eugeroic drug that was developed by the creators of Modafinil to be its successor. The pharmaceutical giant, Cephalon manufactured fluorenol by breaking down fluorine to attain its most significant isomer. The dopamine released by the neurotransmitters in the brain when Fluorenol is taken is lower than that released when Modafinil is consumed, which makes it less likely for methamphetamine addicts to purchase. Experimentation of a varied group of subjects has proved that Flourenol is 39 percent more effective than Modafinil.

4. Pramiracetam

Pramiracetam is a nootropic agent that directly stimulates the central nervous system (CNS) and is usually prescribed for memory and concentration issues that occur due to the brain blood vessel and artery diseases. It helps in improving coordination between the left and right hemispheres of the brain.

Because of its fat-soluble nature, the stimulated choline uptake results in the release of acetylcholine, which is a necessary neurotransmitter for memory and concentration. If combined with oxiracetam, then anti-anxiety effects will take place. This medicine reduces memory loss caused due to amnesiac drugs, improves cognitive function, and also memory retention.

5. L-theanine

L-Theanine is another supplement to Modafinil that helps in advocating wakefulness. For best results, it must be used with caffeine doses of 250 – 400 mg to achieve a greater quality of sleep. Essentially it is an amino acid with benefits brain activity, brainpower, and mental clarity. It also nullifies the negative effects of caffeine.

When a person is consuming L-Theanine pills, the brain emits alpha brain wave signals which advocates increased mental focus, alertness, and mind/body integration. It works differently when crossing the blood-brain barrier, due to its neurotransmitter inhibiting property; lesser dopamine and serotonin are released.

6. Semax

Semax is another nootropic supplement that was originally used only for brain damage cases, but gradually it was recognized for its various health and cognitive effects. Neurotransmitters and receptors such as serotonin, adenosine, acetylcholine, and dopamine are modulated due to the chemical activity that Semax brings to the Limbic Reticular Complex in the brain.

Unlike other supplements, Semax comes with neuroprotective attributes that intensify glutamatergic activity. Another positive trait is that Semax counteracts the damage of brain nerves and cells in sleep apnea patients due to its ability to help neurons survive in situations with reduced oxygen. 

7. Armodafinil

Armodafinil is considered as the first choice for sleeping disorders such as narcolepsy or shift work disorder. The active ingredient known as R-modafinil makes one dosage of the medicine enough for heightened cognitive functionality. 150 – 200 mg of Armodafinil when administered orally, lays a substantial impact on the central nervous system.

Different pharmacologic options such as melatonin and zolpidem when combined can produce varying degrees of results for people with shift work disorders. The bioavailability of the nootropic armodafinil is not altered because of meals, but the absorption and dissolving rate can be delayed by 3-5 hours when taken after dinner. Also, a better half-life can easily be associated with the promoting wakefulness aspect.

Also Read: Everything You Need To Know About Armodafinil

Alternatives To Modafinil: Wrapping Up

There can be multiple reasons that a person is looking for suitable alternatives to Modafinil, such as its high cost, failure of coming up with a prescription, or unsatisfactory results on health. Because of the rise in histamine levels caused by Modafinil, there can be an inflammation of the mucous membrane present in the nose tracts, this is called rhinitis.

There is also an increase in the norepinephrine and dopamine levels, which with other alternatives can be restricted. So that only required neurotransmitters are activated and there is no unnecessary burden on the brain and body. Most importantly, Modafinil provides over 11 hours of an intense increase in cognitive abilities which helps those who want to work in the day and over the night.

What if somebody only needs to be at peak mental performance for 4-6 hours? That is why it is beneficial for the masses to have some knowledge of available alternatives to Modafinil that exhibits the fulfillment of the primary cause of this medicine.