Meloxicam vs Celebrex: Uses, Composition, Dosage And Side Effects

Meloxicam and Celebrex

Meloxicam vs Celebrex

In this article, we will discuss difference between Meloxicam and Celebrex.

Introduction

Meloxicam and Celebrex are nonsteroidal anti-inflammatory drugs (NSAIDs) used to treat arthritis. Meloxicam is sold under the brand name Mobic in the market while Celebrex is the brand name for celecoxib. Meloxicam tablets can be taken by mouth or by injection into a vein while Celebrex is available as a capsule and as a liquid solution in the market.

Uses

Both Meloxicam and Celebrex are used to treat inflammation in the body, and also different kinds of arthritis. They work by preventing the release of inflammatory substances called prostaglandins which can alleviate pain, inflammation, and swelling in the joints. The different uses of these drugs are:

  • Celebrex: It is used to treat arthritis, acute pain, menstrual pain, and menstrual discomfort. Celebrex is also used for ankylosing spondylitis which is the arthritis of the spine.
  • Meloxicam: It is used to treat osteoarthritis and rheumatoid arthritis. It is also used to treat juvenile rheumatoid arthritis which is an autoimmune inflammation in children who are between 2 to 17 years of age and weigh 60 kilograms or more.  

Composition

Meloxicam and Celebrex are both effective in reducing inflammation and pain as it is a COX-2 inhibitor that decreases the production of prostaglandins by blocking the cyclooxygenase (COX-2) enzyme. Both the drugs can be used for short-term or long-term depending on the instructions of the prescribing doctor. The compositions of the drugs are:

  • Celebrex: The capsules are white, hard, and made of gelatine. Each capsule of Celebrex contains 200 mg of celecoxib. The inactive ingredients include croscarmellose sodium and povidone.
  • Meloxicam: Meloxicam, or Mobic, is available as an orodispersible tablet. Meloxicam belongs to a class of organic compounds known as benzothiazines and is composed of mannitol, sorbitol, and aspartame. 

Dosage

  • Celebrex: In case of acute pain, the recommended dose of Celebrex is 400 mg followed by 200 mg if needed on the first day. Thereafter, the recommended dosage is 200mg twice daily as needed. If Celebrex is being administered to treat osteoarthritis, the recommended dosage is 200mg once daily or 100 mg twice daily. While using Celebrex capsule to treat juvenile rheumatoid arthritis, 50 mg should be given twice daily to children between 10 to 25 kg while 100 mg should be given twice daily to children who are greater than 25 kg.
  • Meloxicam: The maximum recommended daily oral dose of Meloxicam is 15 mg regardless of the formulation. In cases where the patient is undergoing dialysis, the maximum recommended dose is 7.5 mg daily. 

Side Effects

Patients who take Meloxicam and Celebrex display some common side effects which include headaches, anxiety or nervousness, runny or clogged nose, sore throat, skin rash, and even dizziness. Some people also complain of abdominal pain and induced insomnia. 

It can also lead to digestive and stomach problems like causing an upset stomach or indigestion, diarrhea, nausea, the formation of gas, and make one feel bloated. 

  • Celebrex: Some side effects of having Celebrex are:
  • Rapid breathing or feeling short of breath
  • Liver problems which might lead to nausea, stomach pain, and dark urine. Patients may also cause heartburn, gas, constipation, and vomiting
  • Symptoms of cold-like stuffy rose, sneezing, sore throat, and dizziness
  • Meloxicam: Some side effects of having Meloxicam are:
  • Digestive problems leading to stomach pain, nausea, vomiting, and heartburn
  • Symptoms of flu or a cold-like congested nose or even chest congestion
  • Dull headaches and dizzy spells due to increased blood pressure. In extreme cases, it may even cause nosebleeds
  • Skin problems like rashes and peeling

Who should avoid taking Celebrex and Meloxicam?

Meloxicam and Celebrex are not recommended for those with heart ailments and especially those who have undergone artery bypass graft surgery, as it might lead to an increase in risk to the cardiovascular health of such patients. NSAIDs increase the risk of heart attacks and stroke.

Those with kidney or liver problems should also avoid taking these drugs as NSAIDs cause an increased risk of stomach and intestinal adverse reactions such as bleeding, ulcers, and perforation of the stomach or intestines. Elderly patients are at a greater risk of these types of reactions.

  • Celebrex: Apart from the aforementioned category of persons, the following should avoid taking Celebrex 
  • Pregnant women or women who are still breastfeeding should avoid using Celebrex as it may harm the child. 
  • Patients with an active stomach or intestinal ulcer or bleeding 
  • Patients with a history of an asthma attack or severe allergic reaction to taking NSAIDs
  • Patients who are into heavy consumption of alcohol and tobacco products
  • Meloxicam: Apart from the aforementioned category of persons, the following should avoid taking Meloxicam:
  • Patients with chronic kidney disease
  • Patients with a history of gastric bypass surgery
  • Patients with a rupture in the wall of the stomach or intestines, or with chronic bleeding in the stomach and intestines
  • Asthmatic patients

Differences between Celebrex and Meloxicam

Celebrex has a wider application as compared to Meloxicam as the latter cannot be used to treat conditions of acute pain or ankylosing spondylitis. Meloxicam can reach peak levels in the bloodstream within six hours of taking a dose. Its effects last longer compared to Celebrex whose effects can be noticed faster but last for a shorter time.

Celebrex is unsuitable for patients with increased blood pressure and those with age-related ailments,. Whereas Meloxicam is unsafe for pregnant women or mothers who are still breastfeeding. 

Drug Interactions

Patients who are going to be administered Celebrex or Meloxicam need to be aware of how they might interact with other drugs that they are taking for the treatment of any subsisting ailments. Some common and potentially fatal interactions of Celebrex and Meloxicam are:

  • Celebrex
  • Use of Celebrex with aspirin increases the chances of occurrence of stomach and intestinal ulcers
  • Celebrex increases lithium in the body and creates the risk of lithium toxicity and therefore, lithium therapy should be monitored while having Celebrex
  • Use of Celebrex with blood thinners may expose the patients to getting low blood pressure
  • Meloxicam
  • It has a negative effect on kidney functioning and impedes the efficiency of drugs taken for kidney-related ailments
  • Meloxicam taken with blood thinners may lead to nosebleeds

Conclusion

Celebrex and Meloxicam are very similar drugs in terms of usage, composition, and the side effects they may produce. It is advisable that they are consumed under proper medical supervision to avoid any extreme side-effects. They should also be prescribed keeping in mind the patient’s medical history and body type.